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Wow! I know Musk is a knobhead, but some of the shit he comes out with is just…unhinged.
Wow! I know Musk is a knobhead, but some of the shit he comes out with is just…unhinged.
Everybody’s saying it
BUt iT WaS a shAm TrIAl!
I mean it sucks for the horse, but that is a bad-ass photo.
If you then get in the shower, the shower becomes a vacuum cleaner cleaner cleaner.
I get it to roughly 303 days from today, which will make a lovely Christmas present.
Abstract
High protein intake is common in western societies and is often promoted as part of a healthy lifestyle; however, amino-acid-mediated mammalian target of rapamycin (mTOR) signalling in macrophages has been implicated in the pathogenesis of ischaemic cardiovascular disease. In a series of clinical studies on male and female participants (NCT03946774 and NCT03994367) that involved graded amounts of protein ingestion together with detailed plasma amino acid analysis and human monocyte/macrophage experiments, we identify leucine as the key activator of mTOR signalling in macrophages. We describe a threshold effect of high protein intake and circulating leucine on monocytes/macrophages wherein only protein in excess of ∼25 g per meal induces mTOR activation and functional effects. By designing specific diets modified in protein and leucine content representative of the intake in the general population, we confirm this threshold effect in mouse models and find ingestion of protein in excess of ∼22% of dietary energy requirements drives atherosclerosis in male mice. These data demonstrate a mechanistic basis for the adverse impact of excessive dietary protein on cardiovascular risk.
His real name is Louie
He goes by Louie, Lewis, Lewis Hamilton, Douglas Luiz, Dougie, Doogie, Dougie Howzer MD, King Louis XIV of France, Doug Larse,.
They called him Fluffy
Fuck the monarchy. Fucking parasites.
Dad: Hey son, next time you’re over, can you have a look at our laptop. it’s running slow for some reason.
Me: Yeh no problem. Have you installed any new programs recently?
Dad: No.
Me: Opens program files, sort by date modified… Shocked Pikachu face
Because they are cruel,heartless bastards, whose sole purpose is to make the wealthy more wealthy, achieved primarily by funneling public money into the hands of their like minded mates.
There are dozens of us, dozens!
Not just chips my friend. Pies, sausages, chicken, salmon. Half the cooking time or an oven, better results and a fraction of the energy use.
The hype is real.
The brain accessed ROM when it should’ve accessed RAM.
Bread and circuses. Keep the plebs fed and entertained, and they will remain docile. This shit has been going on for millennia.
Telecoms project engineer.
I supervise and co-ordinate the roll out of FTTH networks.